Low molecular thiols, pH and O2 modulate H2S-induced S-nitrosoglutathione decomposition – •NO release
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منابع مشابه
Rounding up the usual suspects in O2 sensing: CO, NO, and H2S!
Oxygen sensing by the carotid body is essential in vertebrates to adapt to reduced arterial oxygen tension. In this issue of Science Signaling, Yuan et al. report an intricate signaling system to transduce a physical parameter--oxygen tension--into a biological cellular signal (neural discharge) through changes in the production of carbon monoxide (CO), the second messenger cyclic guanosine mon...
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Ascorbic acid and glutathione (GSH) are important determinants of the intracellular redox state, and both are known to accelerate the decomposition of S-nitrosoglutathione (GSNO), an endogenous adduct of nitric oxide (NO). The implications of these observations for GSNO bioactivity are not yet clear. We investigated the effect of ascorbic acid and GSH on GSNO bioactivity by using a bioassay wit...
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A novel technique has been employed to investigate the simultaneous damage to DNA components induced by soft X rays (1.5 keV) and low-energy electrons (0-30 eV) in thin films of thymidine deposited on glass and tantalum substrates and irradiated under atmospheric pressure and temperature. The films were surrounded by either an N2 or O2 environment. The formation of four radiation-induced produc...
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متن کاملS-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis
INTRODUCTION Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. AIM To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. MATERIALS AND METHODS Oral mucositis was induced in male hamsters by two intraperitoneal admini...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2014
ISSN: 1338-4325
DOI: 10.4149/gpb_2013026